SARS-CoV-2 pseudovirus enters the host cells through spike protein-CD147 in an Arf6-dependent mannerSARS-CoV-2 슈도바이러스는 Arf6 의존적 방식으로 스파이크 단백질-CD147을 통해 숙주 세포에 들어갑니다.Article Published on 2022-12-012022-09-11 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 approach Arf6 blockade CD147 cells clathrin Clathrin-mediated endocytosis clinically coronavirus endocytic endocytic mechanism endocytosis evaluate feasible function host cell host cells Huh-7 cell Huh-7 cells independent independent of indicated infected Vero E6 cells Infection inhibited inhibitor knockdown Localization macropinocytosis pathway Prevent pseudovirus pseudovirus infection public health RAB5A SARS-CoV-2 SARS-CoV-2 entry SARS-COV-2 infection SARS-CoV-2 pseudovirus SARS-CoV-2 pseudovirus infection severe acute respiratory syndrome Coronavirus Spike protein spike protein. Spread the SARS-CoV-2 variant Vero E6 VERO E6 cells viral infection weakened [DOI] 10.1080/22221751.2022.2059403 PMC 바로가기 [Article Type] Article
SARS-CoV-2, SARS-CoV, and MERS-CoV encode circular RNAs of spliceosome-independent originSARS-CoV-2, SARS-CoV 및 MERS-CoV는 spliceosome-independent origin의 원형 RNA를 인코딩합니다.Article Published on 2022-07-012022-09-11 Journal: Journal of medical virology [Category] Coronavirus, COVID19(2023년), SARS, 유전자 메커니즘, 치료기술, 치료제, [키워드] abundance acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 amplified Analysis analysis approaches assays Autoimmune disease Autoimmune diseases betacoronavirus betacoronaviruses breakpoint canonical Chain Reaction characterized Circular circular RNA complementary coronavirus Critical cytoplasmic demonstrated distribution Features Fluorescence highlight homologous Host In situ hybridization infected Vero E6 cells junction mechanism MERS-CoV Middle East Middle East respiratory syndrome Coronavirus N gene not limited offer polymerase chain polymerase chain reaction predicted probe respiratory syndrome coronavirus RNA RNA Biology RNA genome RNA genomes RNA sample RNA samples RNA synthesis RNase SARS-CoV SARS-CoV-2 sequenced severe acute respiratory syndrome Coronavirus transcriptional regulatory sequences Transcriptome Vero E6 VERO E6 cells viral pathogenesis viral transcriptome Virology Virology. [DOI] 10.1002/jmv.27734 PMC 바로가기 [Article Type] Article
Intracellular flow cytometry complements RT-qPCR detection of circulating SARS-CoV-2 variants of concern세포 내 유세포 분석은 순환하는 SARS-CoV-2 변이체의 RT-qPCR 검출을 보완합니다.Article Published on 2022-06-012022-09-11 Journal: BioTechniques [Category] COVID19(2023년), SARS, 변종, 치료기술, 치료법, [키워드] addition Antiviral antiviral drug antiviral drugs basic bystander cells cellular circulating SARS-CoV-2 variant complement detect duplex RT-qPCR expression flow cytometric flow cytometry in vitro infected cell infected cells infected Vero E6 cells Intracellular late phase mutated nucleocapsid omicron Omicron variant omicron variant. released Research RT-qPCR SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant single cell level subpopulation subpopulations the viral nucleocapsid uninfected variant Vero E6 Vero E6 cell VERO E6 cells viral replication virus particle virus particles virus replication virus-infected cell virus-infected cells [DOI] 10.2144/btn-2022-0018 PMC 바로가기 [Article Type] Article
Unraveling the antiviral activity of plitidepsin against SARS-CoV-2 by subcellular and morphological analysis세포내 및 형태학적 분석을 통한 SARS-CoV-2에 대한 플리티뎁신의 항바이러스 활성 규명Article Published on 2022-04-012022-09-11 Journal: Antiviral Research [Category] Coronavirus, COVID19(2023년), SARS, 치료기술, 치료법, 치료제, [키워드] absence Affect Alpha Analysis antitumor agent Antiviral antiviral activity antiviral drugs Antiviral treatment approach biogenesis block caused Cell Complete coronavirus COVID-19 double-stranded RNA dsRNA Efficacy electron electron microscopy elongation factor eukaryotic translation evaluate the effect Extracellular genome replication group host protein infected Vero E6 cells Interaction labeling mechanism mechanism of action Microscopy morphogenesis Morphological morphological analysis New coronavirus new coronavirus SARS-CoV-2 offer organelle pandemic plasma membrane Plitidepsin Post-infection progeny Protein provided SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 nucleocapsid SARS-CoV-2. shown Structure subcellular Support target TEM transmission electron microscopy treated unique Vero E6 Vero E6 cell VERO E6 cells Vesicle viral infection Viral particles viral replication virion virus virus viruses [DOI] 10.1016/j.antiviral.2022.105270 PMC 바로가기 [Article Type] Article
Development of targeted nanoparticles loaded with antiviral drugs for SARS-CoV-2 inhibitionSARS-CoV-2 억제용 항바이러스제를 탑재한 표적 나노입자 개발Article Published on 2022-03-052022-09-11 Journal: European journal of medicinal chemistry [Category] SARS, 치료제, [키워드] ACE2 ACE2 binding site ACE2 protein acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 anti-SARS-CoV-2 Antiviral antiviral activity antiviral drug Antiviral effect antiviral therapeutics binding carriers Concentration coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 development Effectiveness etiological agent evaluated example exhibited host cells identify in viral infected Vero E6 cells Intervention Ligand ligands mechanism membrane Novel coronavirus pandemic Perspective pharmacological plethora prophylactic treatment pulmonary tract raised RDV receptor Regulatory Remdesivir representing Safe SARS-CoV-2 severe acute respiratory syndrome Coronavirus significantly Specific specificity Spike protein Targeted drug delivery Targeted nanoparticles. targets tested therapy for COVID-19 translation Vaccines Vero E6 VERO E6 cells viral entry viral particle Viral particles would increase [DOI] 10.1016/j.ejmech.2022.114121 PMC 바로가기 [Article Type] Article
Indomethacin-based PROTACs as pan-coronavirus antiviral agents범 코로나바이러스 항바이러스제로서의 인도메타신 기반 PROTACArticle Published on 2021-12-152022-09-11 Journal: European journal of medicinal chemistry [Category] SARS, 신약개발, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 addition anti-inflammatory drug Anti-SARS-CoV-2 Activity Antiviral antiviral activity antiviral agent Antiviral agents antiviral potency Chimera class coronavirus coronavirus Coronavirus-2 CoVs demonstrated develop early stage example host protein human CoVs indicated indomethacin infected Vero E6 cells inhibit inhibit SARS-CoV-2 interact knowledge mechanism mechanism of action Nsp7 PGES-2 prostaglandin prostaglandin E PROTAC Protein proteolysis proteomic study Replication reported SARS-CoV-2 SARS-CoV-2 replication SARS-CoV-2 strains SARS-CoV-2. Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus Support synthesis targeting the SARS-CoV-2 Vero E6 VERO E6 cells [DOI] 10.1016/j.ejmech.2021.113814 PMC 바로가기 [Article Type] Article
Targeted proteomics as a tool to detect SARS-CoV-2 proteins in clinical specimens임상 표본에서 SARS-COV-2 단백질을 탐지하는 도구로서 표적화 된 프로테오믹스Research Article Published on 2021-11-112022-09-10 Journal: PLoS ONE [Category] MERS, SARS, 유전자 메커니즘, 치료기술, 치료법, 치료제, [키워드] abundance applied COVID-19 COVID-19 outbreak COVID-19 patient Critical Ct values detect diagnostics infected Vero E6 cells intensity limit of detection mass spectrometry methodology nasopharyngeal swabs nucleocapsid protein PCR peptides Protein proteomics Research SARS-CoV-2 SARS-CoV-2 protein SARS-CoV-2 proteins sensitivity specimen specimens sputum swabs tryptic peptide tryptic peptides Vero E6 VERO E6 cells Viral Viral protein Viral proteins Viral RNA [DOI] 10.1371/journal.pone.0259165 PMC 바로가기 [Article Type] Research Article
Proteomic analysis identifies the RNA helicase DDX3X as a host target against SARS-CoV-2 infection단백질체 분석은 RNA 헬리카제 DDX3X를 SARS-CoV-2 감염에 대한 숙주 표적으로 식별합니다.Article Published on 2021-06-012022-09-11 Journal: Antiviral Research [Category] MERS, SARS, 유전자 메커니즘, 진단, 치료제, [키워드] accumulate aggregate antiviral drugs antiviral therapeutics cellular characterization COVID-19 cytoplasmic DDX3X DEAD RNA helicase develop eIF2α foci G3BP1 granules Health Helicase Host host protein host proteins Host-directed therapies identify infected cell infected cells infected Vero E6 cells Infection involved life cycle metabolism mitigate nucleoprotein Phosphorylation powerful tool Protein proteomic Proteomic analysis proteomics reduce Replication required ribonucleoprotein RNA SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 nucleoprotein SARS-CoV-2 replication scaffold proteins significantly small interfering RNAs small molecule Small molecules Stress stress granule stress granules Stress granules. Structure the SARS-CoV-2 Therapeutic strategies therapeutic strategy translation upstream Vero E6 VERO E6 cells Viral viral replication Viral RNA virus viruses [DOI] 10.1016/j.antiviral.2021.105064 PMC 바로가기 [Article Type] Article